you work together with partners

01 - Maastricht University | CARIM

TTD is working on the development of new diagnostic tools for cardiovascular disease, both on a technical and scientific content level. The partner Maastricht University (UM) has achieved different results in collaboration with the other TTD partners.

- Together with VITO (Centre for Proteomics, University of Antwerp and VITO), a large 'proteomics analysis' was performed on endothelial cells as part of the TTD work package "WP3D2 - Inflammation". The expression of proteins is compared between non-inflamed and inflamed endothelial cells. The data is currently being analyzed. The expectation is that this will provide new insights into which proteins are involved in cardiovascular diseases.

- For "WP3D3 - Metabolic", UM has set up a portfolio of assays that can be used to determine the metabolic status of endothelial cells by means of imaging, as a risk assessment for cardiovascular disease. Through the 2nd MIX-round we hope to find partners with which we can simplify the imaging part of these assays.

- Together with TSG InnoteQ and PPLs Tenco DDM and PimBio, UM is working on the development of an automated 'Dynamic Inflammation Assay'. The interaction between blood vessels and immune system (the basis of many cardiovascular diseases) is studied in vitro, in a miniature and simple way. During the development of the new proof-of-concept model, UM has applied new biological insights to the iterative collaboration with the aforementioned partners to achieve the first 'Dynamic Inflammation Assay' and a first prototype was successfully tested on 18 December 2018; a beautiful success of interregional public-private partnerships that will be developed into a Demonstrator in 2019.

The first prototypes tested in December 2018, the realization of various new R&D assays and infrastructure, the strengthening of our network and the realization of more and also successful collaborations with our colleagues from Belgium and the Netherlands, but also strengthening knowledge and know-how of Maastricht University and its researchers show that European cooperation is strong.

02 - UHasselt | BIOMED

Cardiovascular diseases are the number one cause of death in Europe, costing the European community 196 billion euros per year.

Within the Euregional project 'TransTechDiagnostics' we want to convert laboratory setups, which can demonstrate early indicators of cardiovascular disease, into potential diagnostic tools or kits that can diagnose patients as early as possible. These kits are developed in collaboration with preferably local companies.

In the first part of TTD some developed tests that are eligible for risk analysis were listed and evaluated together with the TTD partners. A biomarker for early inflammation was included in the valorization as an important parameter for risk analysis. Due to the diagnostic potential of this early biomarker, UHasselt/BIOMED is currently investigating the patentability of this biomarker measurement. This method is the only one worldwide that can measure this biomarker in patient samples (e.g. serum). To strengthen and anchor this valorizable knowledge in the region, the joint infrastructure was expanded. At UHasselt the Next Generation Sequencing (NGS) platform was extended and optimized for the research of extracellular vesicles considering their importance as early indicators for cardiovascular diseases. Advanced high resolution imaging technologies were utilized to provide spatial information for these aspects.

At Interreg, cooperation with private partners is considered of eminent importance. Currently, several Flemish companies (e.g. apDia and Fox Biosystems) have shown interest in developing commercial tests for this promising biomarker, which can eventually be used in clinical laboratories.

The obtained results clearly illustrate that we use complementary knowledge and expertise from both public and private institutions in the ‘Grensregio’ in the project 'Trans Tech Diagnostics'. In this context, Fox-Biosystems, a start-up company in the nanotechnology medical biosensor that wants to develop biosensor solutions within TTD, and will start to work as a PPL within TTD on the development of a convenient and affordable biosensor inflammation markers from 2019 onwards.

03 - Vito

VITO is a leading European independent research and technology organization that provides innovative and high-quality solutions to industry and public authorities. It also offers scientifically based advice and support in the domains of chemistry, energy, health, materials management and land use in order to stimulate sustainable development. Research of the Sustainable Health department is in the field of molecular diagnostics and disease prevention, with a focus on technological innovations for personalized diagnostics. This includes

  • biomarkers discovery and validation using multi-omics approaches,
  • technologies for isolation and detection of various biomarker types, with special focus on DNA mutations and extracellular vesicular proteins,
  • data science.

VITO collaborates with various partners, including industry, hospitals and academia, to realize its ambitions.

04 - TSG Group

TSG Group (Total Support Group) is a Dutch company based in Eindhoven with a focus on B2B development of end products, special machines as well as automation and solutions in the field of mechatronics. Our customers are active in the following markets:

• High-Tech Systems & Materials
• Life Science & Health
• Mobility
• Lighting
• Sports & Leisure
• Agri & Food
• Consumer

With nearly 100 specialists, TSG supports its customers with project-related development processes and innovations from idea till production. We also pay attention to analysis, design, engineering and manufacturability. Our engineering and project management skills are combined with extensive knowledge of materials, surface treatments and production processes.
At our workshop in Eindhoven we make prototypes, build special machines and perform pilot series production.

The TSG Group consists of four business units:
TSG Essempio, TSG InnoteQ, TSG Engineering and Finetic.
TSG Essempio focuses on product development including concepts, industrial & UX design, ergonomics, visualization, prototyping and pilot production.
TSG InnoteQ is responsible for projects in the field of special machine development, tooling and Industry 4.0 automation projects.
Working closely together, our project managers, systems architects, engineers, analysts, and designers work together to deliver the best solutions for our customers in specialty machinery, end products, and mechatronics.
The specialists at TSG Engineering also support the customer on a project basis and outsourcing or with technical consultancy.
Sister company Finetic offers website and web application services, such as online strategy, SEO / SEA and product configurators.



BONNÉ+JAN is pronounced "bonnééé plus jan" and is a creative collective. We are working on a mix of various creative disciplines, including graphic design, film and animation.

We work for clients who choose us, our expertise and working methods and mainly for government, semi-government, education and health care in (mainly) the Netherlands and Belgium.

We create designs for books, annual reports, newsletters, magazines, leaflets, brochures, flyers, posters, packaging. But also take care of entire corporate identities. We also produce films/documentaries, instructional videos, drone images, but also animations and motion graphics. Entirely with our own team of professionals.

06 - DSP Valley

MIX is a Multi-disciplinary, Interregional, X-sectoral approach to develop sustainable value models through innovation and knowledge creation. This approach takes into account several success factors. By making people with different expertise, different background and different experience efficiently work together, you reach concrete and tangible solutions. The MIX innovation approach is based on the experiences of the EU CIP project Nano4Health. That project supported the development of personalized healthcare applications at the crossroads of nano- and biotechnologies.

The approach of the TTD-project is based on those MIX principles.

First, 5 steps were defined:
1. Idea Screening & selection
2. Value modelling
3. Team building
4. Plan for Action and
5. Set up teams in which project partners light (PPLs) are included.

Within the running time of TTD, two MIX-rounds are foreseen. The first one was finalized in January 2018, the second one started in November 2018 and is expected to run until March 2019.

Resulting from the first round, three teams have been formed around three projects. All teams include partners from the original TTD-consortium, additional (private) partners, and partners from both Flanders and The Netherlands. The first team (‘Dynamic Inflammation Assay’) started with the original TTD partners UM and TSG InnoteQ, and has added two private partners (PimBio and Tenco DDM) as PPL to the consortium. Currently, the first prototypes leading from this collaboration are being tested within the TTD consortium. The second team is on the verge of adding an addition private partner as PPL to TTD. The third team is making an inventory of possible PPL-partners.

In the second round, again three projects have been defined and several (private) partners have been contacted. Within this round possible additional partners will also be selected. The team building of this round is expected to start in January 2019. The setting up of the teams and inclusion of PPL within the TTD consortium is foreseen from February 2019 onwards.

MIX is a model of DSP Valley. DSP Valley stepped into the TTD team to realize the goals of the TTD project with this model. With the MIX approach, they want to facilitate the transfer of solutions from keyTTD partners - Maastricht University (CARIM), Hasselt University (BIOMED), VITO and TSG InnoteQ - to the market.

07 - PimBIO

PimBio BV is a privately held company founded in 2014 to develop  new and promising microfluidic devices for bioengineering of physiologically relevant living tissue for different applications. The development of a platform technology producing 3D physiologically relevant in vitro model will enable the generation of fully differentiated living tissue types and whole organs which can be used in scientific research, regenerative medicine and industry.

PimBio has the vision to operate as a market leader in the manufacturing of microfluidic devices, by investing in quality, innovation and capacity. PimBio supports the 3Rs, the guiding principles of reduction, refinement and replacement of animal experiments.

The essence for PimBio is to work together with customers on innovative and reliable solutions in the complete trajectory from idea to manufacturing.

The mission of PimBio is to provide research and industrial community a unique combination of micro technologies, materials, microfluidics knowledge and customer application know-how, which enables PimBio to offer customers innovative and sustainable solutions with 3Rs potential to improve people’s lives.

08 - Tenco DDM

With over 10 years of experience and a wide range of prototyping services, Tenco DDM is contributing to a more efficient and sustainable production process. We are active in various sectors such as the medical sector, the automotive industry, the lighting world and product development. Our expertise in the field of 3D printing and prototyping means that innovation can find its way to production more quickly.

With a team of specialists who have experience in various fields such as design and engineering, industrial plastics processing, machining technologies, lacquer finishing and technical coatings, we can offer you a solution in every project phase. This can range from prototypes to small final series product via 3D printing, CNC machining or vacuum casting or larger production runs from injection moulding.

09 - Provincie Limburg (NL)

Limburg is one of the twelve provinces of the Netherlands and is located in the southeast of the country. It is sometimes called Dutch-Limburg when it is necessary to make a distinction with the Flemish province of the same name. The provincial government consists of Provincial States, Provincial Executive and the King's Commissioner.

The government in the provinces is supported by the officials. They prepare the plans and carry out the decisions of the board. At the head of the provincial organization is a provincial secretary / general manager.

The provinces form the link between the municipalities and the empire and are therefore called the middle management. They simply carry out the tasks that are too big for municipalities and too small for the government. The provinces often cooperate with the other authorities (national, municipalities and water boards) and with companies and social organizations.

10 - Provincie Limburg (B)

As a modern board we want to work together closely and integrally. We want to excel as a giver and connecter between people, actors, structures and regions.

11 - Provincie Noord-Brabant

De provincie werkt met overheden, bedrijven en organisaties aan de maatschappelijke opgaven van Brabant. Om te zorgen dat Brabant ook in de toekomst een provincie blijft waar het goed wonen, werken en recreëren is.

De provincie staat voor grote maatschappelijke opgaven. Het provinciebestuur maakt op basis daarvan beleidskeuzes, die zijn vastgelegd in het Bestuursakkoord. De (gekozen) maatschappelijke opgaven én het Bestuursakkoord vormen samen de Concernagenda.

De directie organiseert op basis van de Concernagenda het werk van de organisatie. Dat doet zij programma's en daaronder projecten. De sturing daarop vindt plaats in portfolio's. Elk directielid heeft een portfolio met een bundeling van samenhangende programma’s.  

Voor de uitvoering van die programma's zijn programmamanagers verantwoordelijk. De organisatie ondersteunt hen hierbij optimaal.

12 - Interreg Vlaanderen-Nederland

Interreg Vlaanderen-Nederland subsidieert grensoverschrijdende projecten voor slimme, groene en inclusieve groei. Het wordt gefinancierd vanuit het Europese Fonds voor Regionale Ontwikkeling (EFRO). read more

13 - Ministry of Economic Affairs and Climate Policy

The Ministry promotes the Netherlands as a country of enterprise with a strong international competitive position and an eye for sustainability. It is committed to creating an excellent entrepreneurial business climate, by creating the right conditions and giving entrepreneurs room to innovate and grow. By paying attention to nature and the living environment. By encouraging cooperation between research institutes and businesses. This is how we enhance our leading positions in agriculture, industry, services and energy and invest in a powerful, sustainable country. 

Trans Tech Diagnostics is een Innovatieproject van

Interreg Vlaanderen-Nederland